Look at the smile she serves up in this "mice with human brains" article.
For the most part, her brand of "crazy" seems to be well-meaning, borne of limited experience and intellectual curiosity, not mean-spirited or truly insane.
At one time or another, and at one level or another, haven't we all had a friend like this? A person who has a strong opinion on everything and substantive knowledge about... next to nothing? But they're amusing. If O'Donnell smoked pot, odds are she would be what we call a "granola hippie". "Hey dude, did you know that the man... the man has developed mice with human brains? Really, dude. And all we have to do to eliminate poverty is raise minimum wage to $40 grand a year! Think about it...." All those visits to "Politically Incorrect" and Bill Maher never got her to take even a single toke? (No offense, Bill, even though she's not a blonde it's hard to believe you wouldn't have tried.)